Keyword "4" found in the following publications:

• POLYMORPHISM OF IL10, CTLA4 GENES AND PREDISPOSITION TO RHEUMATOID ARTHRITIS

  Background. Rheumatoid arthritis (RA) is a systemic autoimmune disease, accompanied by chronic inflammation of the joints synovial membrane and ...

  Abstract | Full text (PDF)

• THE TRANSFORMATION OF THE CONTENT OF THE CONCEPT OF THE MARKETING MIX, TAKING INTO ACCOUNT THE DEVELOPMENT OF INFORMATION TECHNOLOGIES

  The high degree of competition, a wide assortment of high-tech products, high requirements of a customer characterize the current stage ...

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• METAPHORS OF THE SUBSPHERE “NATURE” IN THE NOVEL “FAHRENHEIT 451” BY R. BRADBURY

      The development of the theory of cognitivemetaphormakesthe study of metaphoric modelling in different types of discourse, ...

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• ASSESSMENT OF THE DNA DAMAGE LEVEL IN PERIPHERAL BLOOD LEUKOCYTES OF MICE TREATED ORALLY WITH RAPITALAM IN ACUTE AND THERAPEUTIC DOSES

  Rapitalam is a drug that is a modulator of the mglur4 receptor - a kind of metabotropic glutamate receptors. Into ...

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• NOVEL MGLUR4 AGONIST RAPITALAM AMELIORATES MOTOR DYSFUNCTION IN MICE WITH TAU-ASSOCIATED NEURODEGENERATION
   

  Introduction: Tau protein is classically involved in the pathogenesis of a neurodegenerative processes, such as Parkinson’s disease. This study was ...

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• 2Q14 DE NOVO INTERSTITIAL DELETION IN A GIRL WITH INTELLECTUAL DISABILITIES AND MALFORMATIONS

  Background: Neurodevelopmental disorders have a prevalence of approximately 3% in the population, the genetic factor is involved in ...

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•  IMMUNOHISTOCHEMICAL AND MORPHOLOGICAL MARKERS OF SUSCEPTIBILITY TO PROLONGED AND POSTTERM PREGNANCIES
   

  Background: Prolonged pregnancy is an urgent problem, which is associated with a high percentage of complications in childbirth and ...

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• ASSOCIATION OF POLYMORPHISMS OF GENES IN NEUROTRANSMITTER SYSTEMS OF THE BRAIN WITH THE RISK OF DEVELOPING MENTAL DISORDERS IN CHILDREN LEFT WITHOUT PARENTAL CARE

  Background: Social orphans have a variety of behavioural and intellectual disorders. A number of specific polymorphisms in ...

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• FEATURES OF ASSOCIATIONS OF SHBG-RELATED GENES WITH BREAST CANCER IN WOMEN, DEPENDING ON THE PRESENCE OF HEREDITARY BURDEN AND MUTATIONS IN THE BRCA1/CHEK2 GENES

  Background: One of the most common diseases of the female population is breast cancer (BC), which is ...

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• ZNF804A RS1344706 GENE POLYMORPHISM AND CLINICAL HETEROGENEITY OF SCHIZOPHRENIA
   

  Background: Replication of genome-wide association study (GWAS) loci for schizophrenia in different populations as well as the study ...

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• ASSESSMENT OF PHARMACOLOGICAL ACTIVITY AND BIOAVAILABILITY OF THE NEW DERIVATIVE 1,3,4-THIADIAZOLE

  Introduction: Acexazolamide is a new derivative of 1,3,4-thiadiazole and acexamic acid.

  Materials and Methods: In animal experiments, acute ...

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• FELIX ZU SCHWARZENBERG AND LUDWIG VON DER PFORDTEN: TWO VIEWS ON THE GREATER GERMAN WAY OF THE UNIFICATION OF GERMANY IN 1848-1849

  The article provides a comparative analysis of the formation and interconnection of the political courses of the Ministers of Foreign ...

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• ABOUT THE ORIGIN OF THE ACROCENTRIC PART OF NON-ACROCENTRIC SATELLITED CHROMOSOMES IN HUMANS
   

  Background: Variants in size of the acrocentric short arms (acro-ps) are normally not reported and considered as chromosomal ...

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• MECHANISM OF NEUROPROTECTIVE EFFECT OF MGLUR4 AGONISTS

  Introduction: This review of literature is to demonstrate a role of group III metabotropic glutamate receptors in maintaining the level ...

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• CARDIOVASCULAR EFFECTS OF AN ARGINASE II SELECTIVE INHIBITOR

  For the first time in vitro experiments there were studied the inhibitory activity and safety of potential molecules arginase II ...

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• TEST-SYSTEM FOR ESTIMATION OF ACTIVITY OF GSK-3 INHIBITORS AS ANTIHYPOXANTS AND DIFFERENTIATION OF ENDOTHELIAL PROGENITORS IN VITRO

  A model test-system was developed for validation in vitro of antihypoxic and endothelio-differentiating activity of newly created glycogen synthase kinase-3 ...

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• THE DIALOGUE OF HALF A CENTURY: TO THE HISTORY OF THE RELATIONSHIPBETWEEN YAKOV POLONSKY AND AFANASY FET-SHENSHIN
   

  In the history of philosophy and the history of intellectual culture the nineteenth century is much more thoroughly studied than ...

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• CHOICE OF ANTIHYPERTENSIVE THERAPY IN HYPERTENSIVE PATIENTS WITH CRITICAL CORONARY ARTERY STENOSIS

  Sixty patients with stages II-III AH were studied. ABPM was performed in all the patients. DBPP was assessed by the ...

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• JOHANN CARL BERTRAM STÜVE AND THE PROBLEM OF GERMAN UNIFICATION IN 1848–1849

  This article examines the views and policies of the Hanoverian minister Johann Carl Berthram Stüve during the 1848 revolution in ...

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• NUMERICAL SOLUTION BY THE SELF-CONSISTENT BASIS METHOD OF SCHRÖDINGER EQUATIONS THAT ARE INVARIANT WITH RESPECT TRANSFORMATIONS OF DISCRETE CNV GROUPS

  In this work, using the so-called self-consistent basis method, solutions to three two-dimensional Schrödinger equations are found, which ...

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• ASSOCIATION OF POLYMORPHIC LOCUS RS4880 OF SUPEROXIDE DISMUTASE 2 GENE (SOD2) WITH POLYCYSTIC OVARY SYNDROME: A META-ANALYSIS
   

  Background: According to WHO, approximately 8-13% of women of reproductive age suffer from polycystic ovary syndrome (PCOS), ...

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• METHODOLOGY OF THE ANALYSIS OF THE SOCIAL SYSTEMS DYNAMICS

  Current globalization is both a system and dynamic but inherently contradictory process marked with a growth of geopolitical conflicts ...

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• ROLE OF OREXIN PEPTIDE SYSTEMINEMOTIONAL OVEREATINGINDUCED BY BRAIN REWARD STIMULATION IN FED RATS

  Introduction: The purpose of this work was to prove that the reaction of food self-deprivation in “fed up” rats is ...

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• SCREENING OF ANXIOLYTIC PROPERTIES AND ANALYSIS OF STRUCTURE-ACTIVITY RELATIONSHIP OF NEW DERIVATIVES OF 6-(4-METHOXY)-7H-[1,2,4]TRIAZOLO[3,4-A][2,3]BENZODIAZEPINE
  UNDER THE CODE RD
   

  Introduction: Searching for new compounds with anti-anxiety activity resulting from the combination of privileged scaffolds is a promising direction ...

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• DEVELOPMENT OF ECOLOGICAL TOURISM IN PROTECTED

  The article discusses the prospects for the development of eco-tourism on the basis of specially protected natural territories of the ...

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• THYMOSIN Β4 AS BASIS FOR CREATION OF A REPARATION PREPARATION OF NEW GENERATION

  In article is narrated about Thymosin β4. Its structure, a number of strategically important properties and opportunities is described. The ...

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• DEVELOPMENT OF AN INTELLIGENT SYSTEM FOR AUTOMATIC RESPONSE TO CUSTOMER REVIEWS ON MARKETPLACES WITH USING LLM

  The article discusses an approach to the development of an intelligent system designed for automatic responses ...

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• ADAPTIVE DESIGN IN CLINICAL DEVELOPMENT OF NEXT-IN-CLASS DRUGS

  Introduction: The next-in-class drugs are the original drugs that by chemical structure and mode of action similar to their ...

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• HISTORY AND CONVERGENT TECHNOLOGIES

  Rapid technological development, accelerated in the XXI century, poses new challenges for the social sciences, including historical knowledge. As we ...

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• SINGLE NUCLEOTIDE POLYMORPHISMS IN GENES ENCODING XENOBIOTIC METABOLIZING ENZYMES ARE ASSOCIATED WITH PREDISPOSITION TO ARTERIAL HYPERTENSION
   

  Background: Arterial hypertension (AH) is the most common disease of the cardiovascular system. Intracellular chemical and oxidative stress, ...

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• UBIQUINOL AMELIORATES ENDOTHELIAL DYSFUNCTION AND INCREASES EXPRESSION OF MIRNA-34A IN A RAT MODEL OF PULMONARY HYPERTENSION

  Introduction: In this research, we evaluate the effect of intravenously administrated solubilized ubiquinol on 4-week monocrotalin-induced pulmonary hypertension ...

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• SCRUTINIZING THE CONSUMERS PREFERENCES OF SMART WATCHES AS THE PREREQUISITE FOR SUBSTANTIATING THE NEED FOR A SOCIAL ELEMENT IN MARKETING RESEARCH

  The scientific article contains 1 table and 5 figures. There are 14 pages in the article. The author determines ...

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• THE MODERNIZATION OF INDUSTRIAL ENTERPRISES IN THE DIGITAL ECONOMY OF THE EURASIAN ECONOMIC UNION

  The relevance of this study is due to the need to develop the industrial sector in the EAEU countries and ...

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• A STUDY OF NEUROPROTECTIVE PROPERTIES OF THE MGLUR4 RECEPTOR AGONIST – ZC64-0001 IN COMPARISON WITH MEXIDOL
   

  Background: One of the most common neurodegenerative diseases is Parkinson's disease, which is based on the degeneration of dopaminergic ...

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• SYNTHESIS OF BACTERIOCIN-LIKE SUBSTANCE BY LACTOBACILLUS PLANTARUM 42 STRAIN ISOLATED FROM SOUR CABBAGE

  Bacteriocins are ribosomally synthesized antibacterial peptides secreted by certain types of bacteria and are active against both closely related species,and ...

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• INVESTIGATION OF THE ACTIVITY OF NEW DERIVATIVES OF 1,3-DIAZINONE-4 AND THEIR ACYCLIC PRECURSORS WITH RESPECT TO BACTERIA OF THE GENUS PROTEUS

  Introduction: The present paper provides a study of the activity of the new 1,3-diazinon-4 derivatives and their acyclic precursors ...

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• RISKS OF DIGITAL TRANSFORMATION OF REGIONAL ECONOMIC SYSTEMS AND DIRECTIONS FOR THEIR REGULATION

  The article analyzes the risks of digital transformation that regional economic systems face at the present stage of ...

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